Catherine Kehoe was born in Hartford, Connecticut.
She received her BFA in painting from Massachusetts College of Art and Design in 1989 and her MFA in painting from the School of Visual Arts, Boston University, in 1992.

Kehoe has received the following awards: Lillian Orlowsky and William Freed Foundation Grant; Pollock-Krasner Foundation Grant; Berkshire Taconic Artist’s Resource Trust Grant; Massachusetts Cultural Council Finalist Grant; Blanche E. Colman Award; St. Botolph Club Foundation Grant, and the Sam and Adele Golden Foundation for the Arts Award.

Kehoe is represented by Howard Yezerski Gallery, Boston, where she has had several solo shows.  

Kehoe has been a visting artist at Rhode Island College, Colby College, University of Arkansas at Fort Smith, Indiana University, Boston University School of Visual Arts, and the School of the Museum of Fine Arts, Boston.

She teaches painting at Massachusetts College of Art and Design, and has taught drawing at Boston University School of Visual Arts. Kehoe has also taught painting workshops at Art New England at Bennington College, The Fine Arts Work Center in Provincetown, the Washington Art Association, and at a program of the Jerusalem Studio School in Siena, Italy.